highly significantP = .00003
We reported co-occurring mutations in TP53 and PTEN , and in PIK3CA and TP53 , and a highly significant enrichment for trios of co-occurring mutations in TP53, PIK3CA , and PTEN (n = 3/30; P = .00003) as compared with TCGA (The Cancer Genome Atlas) breast cancer exome sequence data.