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Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil.

Clinics (Sao Paulo) · 2019 · PMC6536091 · PMID 31090796

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an increasing trendno p-value reported
An increasing trend of OS incidence was observed for females at younger ages, raising the question whether the earlier exposure to estrogen (due to the earlier puberty) could be involved with this shift.

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