Bioinformatic Analysis of Gene Variants from Gastroschisis Recurrence Identifies Multiple Novel Pathogenetic Pathways: Implication for the Closure of the Ventral Body Wall.

Novel Candidate Genes and Pathogenetic Pathways Several genes could be potential candidates for future studies as those observed with a highly significant functional enrichment, high connectivity/direct protein-protein interactions, and highest score for dominant, recessive, and heterozygous compound models ( UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, AOX1, NOTCH1, HIST1H2BB, RPS3, THBS1, ADCY9, FGFR4, OR10G4 , ITIH3 , PLEKHG4B , SLC9A3 , ITGA2 , ALPP, PER2 , PTPRD , CDYL , KDM5A , RASGRP1 , MYBPC2 , PDE4DIP , F5 , and OBSCN ) ( Table 1 and Tables S1–S3 , Figure 1 , Figure 2 and Figure 3 ).

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