Early effects of roflumilast on insulin sensitivity in adults with prediabetes and overweight/obesity involve age-associated fat mass loss - results of an exploratory study.

Roflumilast induced a trend toward significance in 1) decreased energy intake (from 11,095 KJ to 8,4555 KJ, P =0.07), 2) decreased fat mass (from 34.53 to 32.97 kg, P =0.06), 3) decreased total and LDL cholesterol ( P =0.06 for both variables), and 4) increased plasma free fatty acids (from 0.40 to 0.50 mEq/L, P =0.09) The interval changes in adiposity and free fatty acid were significantly associated with the subject’s age ( P -value range= <0.001 to 0.02 for the correlations).

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