Overcoming chemotherapy resistance <i>via</i> simultaneous drug-efflux circumvention and mitochondrial targeting.

Acta Pharm Sin B · 2019 · PMC6542785 · PMID 31193791

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highly significantno p-value reported

The Statistically significant difference was defined as P <0.05 and highly significant difference was defined as P <0.01. 3 Result and discussion 3.1 Macromolecular HPMA vehicle bypasses drug efflux in resistant cells The mitochondria-targeting HPMA copolymer-doxorubicin conjugates (P-M-Dox) with pH sensitivity were successfully synthesized by three steps ( Supporting Information Scheme S1 ).

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