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MLST typing of Treponema pallidum subsp. pallidum in the Czech Republic during 2004-2017: Clinical isolates belonged to 25 allelic profiles and harbored 8 novel allelic variants.

PLoS One · 2019 · PMC6544256 · PMID 31150464

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a decreasing trendno p-value reported
While there is a decreasing trend in the use of spiramycin, azithromycin is being prescribed more frequently [ 4 ].

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an increasing trendno p-value reported
While there is an increasing trend in the number of samples containing A2058G mutations (86.7% in 2016/2017), the number of A2059G mutations has decreased over time (3.3% in 2016/2017).

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.