Detecting interaction networks in the human microbiome with conditional Granger causality.

Although our analysis cannot rely on these recently developed approaches to minimize the impact of compositionality, we have employed a stringent LASSO shrinkage of the model that eliminated three-fourths of the coefficients, retaining only the very strongest and most highly significant relationships.

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Interestingly, although this same trend appears marginally significant at long timescales in the gut, it does not apply to long timescale interactions at other body sites, where there appears no discernable relationship between Pearson and Granger causality results (See S1 – S8 Tables).

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