'Why genes in pieces?'-revisited.

Nucleic Acids Res · 2019 · PMC6547436 · PMID 30997511

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an overall trendno p-value reported

Whilst it is not the case that all domains align with exon boundaries (symmetric or otherwise), which hampered the earliest attempts to determine such a correspondence, these more recent studies do show an overall trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.