Barely Significant
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Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.

ACS Omega · 2019 · PMC6547624 · PMID 31179408

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an interesting trendno p-value reported
An interesting trend emerges: the more electronegative substituent of the two faces Fe 2+ .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.