In a meta-analysis study to investigate the association between metformin and overall survival in patients with pancreatic cancer and concurrent type 2 diabetes, a borderline significant relative survival benefit was found in metformin-treated patients compared with non-metformin treated patients 46 .
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Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells.
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