closely significantP =0.050
In the analyses on factors associated with OS using Cox proportional model, however, univariate analysis determined that age >60 years ( P =0.001), ≥2 ECOG ( P =0.009), elevated LDH ( P =0.001), stage III-IV ( P =0.000), ≥2 extranodal sites ( P =0.001), IPI 3-5( P =0.000) and B symptom ( P =0.001) were closely significant while high Bcl-2 expression was marginally correlated ( P =0.050).