borderline significantp =0.077
The other two studies examined both early and late failures and failed to find a statistically significant result, although Jacobi-Gresser et al found a borderline significant association ( p =0.077). 24 The IL-1A interleukin has been previously linked to peri-implantitis, which is one of the most common causes of late implant failure. 28 The only study which showed a statistically significant association between the IL-1A polymorphism and implant failure, however, was the study which examined only early implant failures.