Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids.

Among our observed novel interactions, some may be significant, and fall into a few categories ( Table 6 ).

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Some of these findings are likely to be significant at therapeutic doses, such as σ1R binding that is only 2.3 fold over MOR affinity for hydrocodone and approximately equal affinity to MOR for tapentadol.

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