Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system.

PLoS One · 2019 · PMC6553724 · PMID 31170204

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an increasing trendno p-value reported

Such an increasing trend was also observed in South America (the HPE prevalence after 1996 was nearly twice of the prevalence before 1996).

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