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A Major Role for the Lateral Habenula in Depressive Illness: Physiologic and Molecular Mechanisms.

Front Psychiatry · 2019 · PMC6558383 · PMID 31231247

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Specifically, the lateral habenula appears to have a critical role in regulating oscillatory theta hippocampal activity through modulation of temporal dopaminergic and serotoninergic firing pattern, suggesting a synaptic mechanism for memory consolidation during REM sleep, a decrease in slow wave sleep, and a highly significant increase in REM sleep ( 16 , 28 ).

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