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Switch rates, time-to-switch, and switch patterns of antiretroviral therapy in people living with human immunodeficiency virus in Japan, in a hospital-claim database.

BMC Infect Dis · 2019 · PMC6558763 · PMID 31182050

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an increasing trendno p-value reported
Our results showed an increasing trend of INSTI prescriptions as an anchor drug class and a predominant prescription of TDF comprising approximately two-thirds of backbone prescriptions as the first regimen in recent years.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.