Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis.

Here, we studied those outcomes that had shown significant (or marginally significant) changes in previous reports ( 2 , 8 ), which were the following: the total cholesterol level, EDSS, Multiple Sclerosis Impact Scale-29v2 (MSIS-29v2) (total score and physical subscale) ( 11 ), Wechsler Abbreviated Test of Intelligence (WASI) block design test (T score) ( 12 ), paced-auditory serial addition test (PASAT) ( 13 ), and Frontal Assessment Battery (FAB) ( 14 ).

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