When comparing the average total levels of H3K14ac (given by the sum of H3K14ac, H3K9me1/K14ac, H3K9me2/K14ac, H3K9me3/K14ac, and H3K9ac/K14ac) in the normal-tumor pairs for all the tumor types tested, we found a highly significant decrease in tumor samples, with a paired t -test p -value of 0.00013 ( Figure 1 E).
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Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer.
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