highly significantp < 0.001
Differences were significant if p < 0.05, highly significant when p < 0.001 or p < 0.0001 and a trend was considered if 0.05 ≤ p < 0.10.
Differences were significant if p < 0.05, highly significant when p < 0.001 or p < 0.0001 and a trend was considered if 0.05 ≤ p < 0.10.