Specifically, the ability of CaV1.3 silencing to reverse peak‐dose LIDs showed a nonsignificant trend of decreasing LID severity in the rAAV‐CaV1.3‐shRNA group (Fig. 2 B,C) compared with the rAAV‐Scr‐shRNA group beginning on day 20 postvector.
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Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia.
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