In any case, in the multivariate proportional hazards Cox regression analysis, the higher tertile of OPN almost reached statistical significance (Hazard Ratio: 2.9; p = 0.088; data not shown) so probably, the relatively low number of events precluded the analysis from having enough potency to show the association of OPN levels with CVE.
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The rs1126616 Single Nucleotide Polymorphism of the Osteopontin Gene Is Independently Associated with Cardiovascular Events in a Chronic Kidney Disease Cohort.
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