Next, we analyzed the expression levels of these same genes in array data of 22 paired HPV-negative oral cancers and oral mucosa to investigate changed expression in malignant cells, and showed a highly significant 2.7-fold upregulation of CHEK1 mRNA in cancers as compared to oral mucosa.
← all excerpts
Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death.
1
—
—