Systematic Review of Sleep Disturbances and Circadian Sleep Desynchronization in Autism Spectrum Disorder: Toward an Integrative Model of a Self-Reinforcing Loop.

Front Psychiatry · 2019 · PMC6581070 · PMID 31244687

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highly significantno p-value reported

Forty-three individuals with ASD revealed a highly significant decrease of ASMT activity and melatonin level compared to 48 controls.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.