borderline significantP = 0.073
Correlation of Biomarkers With Histological Joint Degeneration Looking at the correlation of serum concentration from the four selected biomarkers with the determined metabolic parameters (body weight, glucose, insulin, HOMA-IR, and cholesterol), only serum values of Fib3-3 showed a borderline significant positive correlation with the total body weight ( r = 0.316; P = 0.073) and an unexpected negative correlation with total cholesterol ( r = −0.503; P = 0.003) at endpoint.