The local mammalian target of rapamycin (mTOR) modulation: a promising strategy to counteract neurodegeneration.

Neural Regen Res · 2019 · PMC6585559 · PMID 31169184

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highly significantno p-value reported

Since its first publication in 2003, we know that all pathological hallmarks and cognitive deficits of the 3×Tg-AD mouse are highly significant by 6 months of age.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.