Cathepsin L Causes Proteolytic Cleavage of Chinese-Hamster-Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation.

Biotechnol Prog · 2019 · PMC6587562 · PMID 30320962

Europe PMC DOI

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an interesting trendno p-value reported

As expected, both Fab A and Cathepsin L were more strongly retained at lower pH, but an interesting trend was observed where the protease eluted ahead of the Fab A peak at higher pH, while Fab A eluted ahead of the protease at lower pH.

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