A positive trend (high R -square values) of observed decrease ( r 2 = 0.7333) or increase in methylation percent ( r 2 = 0.7001) linked to the age of blood samples was shown on the line charts of Figures 6 and 7 , respectively.
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Methylation Marks of Blood Leukocytes of Native Hucul Mares Differentiated in Age.
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The sentences
Highly significant differences between groups included 51 age-related differentially methylated regions of hypomethylation during the juvenile to aged period and 14 age DMR sites of the state of hypermethylation.
The expression differences for the other one hypermethylated (TIAM1) and three hypomethylated loci (CENPU, PTPN11, and XYLT2) were significant, and in case of a single gene (PIP4K2A), there was only a statistical trend.