Barely Significant
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The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response.

Front Immunol · 2019 · PMC6591464 · PMID 31275320

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highly significantno p-value reported
The combined IL-1β (2 g/ml) + TNF (5 ng/ml) stimulation induced a highly significant transcription of genes known to shape the aggressive phenotype of RA FLS.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.