Barely Significant
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Homocysteine and small vessel stroke: A mendelian randomization analysis.

Ann Neurol · 2019 · PMC6594149 · PMID 30785218

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marginally significantno p-value reported
A secondary analysis of the largest trial of homocysteine‐lowering therapy in patients with stroke or transient ischemic attack, VITATOPS (The VITAmins TO Prevent Stroke), showed a marginally significant treatment effect for SVS, but not other stroke subtypes. 10 A magnetic resonance imaging (MRI) substudy embedded in the same trial showed that homocysteine‐lowering therapy significantly reduced the progression of white matter hyperintensities (an MRI marker of small vessel disease). 11 Although it

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