Barely Significant
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Comparison of frictional forces during the closure of extraction spaces in passive self-ligating brackets and conventionally ligated brackets using the finite element method.

J Clin Exp Dent · 2019 · PMC6599702 · PMID 31275516

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highly significantno p-value reported
Since the ligation method produces highly significant differences in friction, several modifications of brackets to control ligation stress and reduce friction, between archwire and slot have been created, integrating ligation systems such as the self-ligating brackets ( 5 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.