Noggin depletion in adipocytes promotes obesity in mice.

The differences were highly significant in both genders of the Nog fl/fl ; Adipoq Cre mice after one year ( Figure 3 A) when the females had nearly doubled their body weight.

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The results showed that all the BAT markers and thermogenic genes decreased or showed a decreasing trend in female Nog fl/fl ; Adipoq Cre mice ( Figure 5 A), whereas only Dio2 and Zic1 showed an early decrease (at 2 months) in male Nog fl/fl ; Adipoq Cre mice ( Figure 5 A).

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We also noted an increase in glucose and an increasing trend in insulin levels in the Nog fl/fl ; Adipoq Cre mice ( Supplemental Fig. 6A ), suggesting that the mice were developing glucose intolerance.

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