An <i>in vitro</i> FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.

MAbs · 2019 · PMC6601550 · PMID 30982394

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an apparent trendno p-value reported

The wide ranges of assay results and clearance values further indicate the substantial diversity of the mAbs tested in this study. As shown in Figure 3(a ), an apparent trend of association was observed between the transcytosis outputs and clearance of the mAbs ( R 2 > 0.8).

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