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Prenatal diagnosis and prevalence of critical congenital heart defects: an international retrospective cohort study.

BMJ Open · 2019 · PMC6609145 · PMID 31270117

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an increasing trendno p-value reported
Most programmes showed an increasing trend in prenatally diagnosed CCHD cases.

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a decreasing trendno p-value reported
During the study period, CCHD showed an increasing trend in total prevalence in France-Rhone Alpes and USA-Arkansas, a decreasing trend in the Czech Republic and USA-Atlanta, and more complex trends in Northern Netherlands and Germany-Saxony Anhalt (online supplementary table S1 ).

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