Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards.

In contrast to level of cognition, we observed highly significant nonlinear associations of age with global AD pathology score for which the evidence was much stronger than the association with binary AD diagnosis (χ 2 (3) = 23.6, p < 0.001), β-amyloid load (χ 2 (3) = 15.9, p = 0.001), and PHFtau tangle density (χ 2 (3) = 13.4, p = 0.004) (Fig. 2 b, black, red, and green, respectively).

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