Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress.

Sci Rep · 2019 · PMC6610132 · PMID 31270372

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0990

boldest claim

The sentences

highly significantp < 10 −15actually significant

Analyzing the AMΦ data with linear models to control for batch effects, we found a highly significant effect of CSE concentration (p < 10 −15 ) on phagocytosis.

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marginally significantp = 0.099so close (0.05 < p ≤ 0.1)

Under these conditions we found that lumacaftor significantly reduces THP-1 phagocytosis (p < 0.01), and a marginally significant trend (p = 0.099) suggesting that ivacaftor may also reduce phagocytosis.

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a trend towards significanceno p-value reported

In THP-1, NAC had a greater effect when it was added to the medium after the hydrogen peroxide or CSE (NAC PostTx) rather than before (NAC preTx), reaching statistical significance in both cases by paired t-tests, whereas pre-treatment with NAC only produced a trend towards significance.

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