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The antibiotic resistance of Helicobacter pylori to five antibiotics and influencing factors in an area of China with a high risk of gastric cancer.

BMC Microbiol · 2019 · PMC6611032 · PMID 31272365

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an increasing trendno p-value reported
The resistance rates to levofloxacin and amoxicillin, as well as multidrug resistance, have demonstrated an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.