The addition of chemotherapy to radiotherapy did not reduce the rate of distant metastases in low-risk HPV-related oropharyngeal cancer in a real-world setting.

When the analysis was performed for the HPV‐positive cohort (Table 3 ), the only statistically significant factor was T4 (HR, 4.12 [1.17‐14.57]) with only a trend toward significance in the very small number of N3 cases in the study ( n = 17).

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