A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice.

Values for bufuralol could not be calculated, but for the other four drugs, 2.7- to 4.8-fold increases in area under the curve (AUC) were observed, together with 60–70% decreases in drug clearance (Table 1 ). Of the changes in clearance, those for tolbutamide (adjusted P = 0.0198) and buproprion (adjusted P = 0.00096) were statistically significant, and that for midazolam marginally failed to reach significance (adjusted P = 0.0524).

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