Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).

However, since the association between serological clusters and disease severity remained highly significant (P < 0.001) after excluding data from the 2008 samples, this confounding was not responsible for the association, as might be the case, for example, if the frequency of severe malaria-causing genotypes in the population changed from year to year.

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