Cell Density Effects in Different Cell Culture Media and Their Impact on the Propagation of Foot-And-Mouth Disease Virus.

Independent of the culture media, the viral titer ranged roughly between 6.6 and 7.6 log 10 TCID 50 per mL with an increasing trend, albeit without statistical significance, towards a higher viral yield with increasing cell density ( Figure 2 , panel A–C).

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Up to 1.7% of antifoam in the cell culture media had no significant impact on the viral yield, even though a decreasing trend was evident above a concentration of 0.3%.

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