Relationship of reduced glomerular filtration rate with alterations in plasma free amino acids and uric acid evaluated in healthy control and hypertensive subjects.

As revealed, the differences between the healthy control and hypertension groups remained highly significant (Mann-Whitney U-test, P < 0.01 to 0.001) for the relevant demographic and clinical variables after such categorization except for LDLC and UA for the subjects with reduced eGFR (Table 1 ).

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In another study, compared to normal values, patients with moderate renal failure (average creatinine clearance, 32–88 ml/min) showed a significant increase in Ala, Cit, Gly, Lys, Orn, Phe, Pro and Val (P < 0.005 to 0.001); conversely, Arg and Ser showed a decreasing trend although not significant 27 .

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