Ca<sup>2+</sup> signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats.

Br J Pharmacol · 2019 · PMC6637043 · PMID 31124139

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almost significantlyno p-value reported

Real‐time PCR analysis indicated that except for CD40 , GLMN , and TRAP1 , the expression of the other 20 genes was almost significantly down‐regulated in our AIA model treated with celastrol, whereas co‐treatment with the Ca 2+ chelator, BAPTA/AM abolished the down‐regulation of genes mediated by celastrol (Figure 7 ).

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