Meta-Analysis of the Effects of the Catechol-O-Methyltransferase Val158/108Met Polymorphism on Parkinson's Disease Susceptibility and Cognitive Dysfunction.

Front Genet · 2019 · PMC6639434 · PMID 31354790

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

marginally significantP = 0.053so close (0.05 < p ≤ 0.1)

However, the gender-stratified analyses revealed marginally significant effects in heterozygote model analyses in women ( P = 0.053).

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borderline significantP = 0.053so close (0.05 < p ≤ 0.1)

In the gender subgroup, no significant association was detected under all the genetic models, except that a borderline significant association was detected of female PD in the heterozygous genetic models (OR, 1.32; 95% CI, 1.00–1.74; P = 0.053) in the pooled populations ( Figure 3 , Table 4 ).

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marginal significanceno p-value reported

First, there is marginal significance among female PD patients, which encourages us; further research on the association of gender of PD and COMT Val158/108Met polymorphism should be carried out.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.