Fabrication of Core-Shell-Structured Organic-Inorganic Hybrid Nanocatalyst for the Expedient Synthesis of Polysubstituted Oxazoles via Tandem Oxidative Cyclization Pathway.

9 Indeed, it is the enduring efficiency and overall esthetic appeal of these processes that have prompted chemists to explore novel reaction cascades for the synthesis of complex polycyclic ring skeletons, which serve as important scaffolds of natural products with important bioactivities. In this direction, the recent attempts to obtain the exceedingly significant biologically active polysubstituted oxazole moieties using the copper-catalyzed tandem oxidative cyclization (TOC) pathway are worth applauding. 10 − 15 Although this strategy presents a convincible methodological refinement over the classical procedures in terms of the drastic enhancement in atom economy and reaction conditions, yet the exploitation of homogeneous metal salt as the catalyst renders its commercial utility rather bleak because of the associated problems of separation and recovery.

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