PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.

EBioMedicine · 2019 · PMC6642334 · PMID 31279780

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highly significantno p-value reported

Using the database of spliced-expressed sequence tags, Elnitski LL [ 23 ] found that highly significant enrichment of bidirectional promoters in genes was implicated in somatic cancer, which suggests that bidirectional promoter pairs have a propensity of being involved in cancer.

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