highly significantp < 0.01
Moreover, the adequate precision value of the model was 221.14, suggesting a strong signal compared to noise ratio and the model could be used to navigate the design space. Based on the ANOVA table (Table 4 ), 20 out of the 22 studied medium components affected the growth of the isolate significantly (p < 0.05) and 5 of them (glucose, molasses, yeast extract, meat extract and (NH 4 ) 2 SO 4 were highly significant (p < 0.01).