Barely Significant
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Tandem Double [3 + 2] Cycloaddition Reactions at Both C-1 and C-3 Atoms of <i>N</i>-Cyanomethylisoquinolinium Ylide.

ACS Omega · 2017 · PMC6645381 · PMID 31457339

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might be significantno p-value reported
The reaction originated from the versatile reactivity of the well-known heteroaromatic N -ylides and successfully revealed a new reaction pattern for isoquinolinium ylides in heterocyclic synthesis. The potential applications of this convenient synthetic protocol in organic and medicinal chemistry might be significant.

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