PrPC knockdown by liposome-siRNA-peptide complexes (LSPCs) prolongs survival and normal behavior of prion-infected mice immunotolerant to treatment.

Proteinase K digestion and western blot analysis of brains from prion-infected mice showed PrP Res deposition at terminal disease, with brains from 5 of 6 responder animals appearing to harbor relatively less PrP Res than most non-responders or infected untreated controls, although densitometry revealed these differences to be not quite statistically significant (p = 0.057 and 0.072, respectively, Fig 3B and 3C ).

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