Glycemic Control, Preexisting Cardiovascular Disease, and Risk of Major Cardiovascular Events in Patients with Type 2 Diabetes Mellitus: Systematic Review With Meta-Analysis of Cardiovascular Outcome Trials and Intensive Glucose Control Trials.

J Am Heart Assoc · 2019 · PMC6645638 · PMID 31166153

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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The sentences

highly significantP =0.001actually significant

The overall analysis of the 12 CVOTs showed a highly significant ( P =0.001) 8% reduction of MACE risk associated with no publication bias (Egger test, P =0.210) and significant heterogeneity (I 2 =45.8%, P =0.041), indicating the lack of homogeneity in the whole analysis that grouped 3 different classes of glucose‐lowering drugs.

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