CRISPR/Cas9 Mutagenesis and Expression of Dominant Mutant Transgenes as Functional Genomic Approaches in Parasitic Nematodes.

There was a decreasing trend in the frequency of phenotypes with increasing concentration of wild-type vector plasmid, confirming the specificity of the mutant constructs dominant effect ( Castelletto et al., 2009 ; Yuan et al., 2017 ).

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